My current research centers on Systems Biology approaches to understanding molecular mechanisms regulating cellular phenotypes, in particular focusing on the transformation from a physiologic to a pathologic state. A particular angle of interest is the integration of large scale genomic, transcriptomic, epigenetic, proteomic, and metabolomic data to derive a molecular “holistic” approach to understanding the development of gastro-intestinal cancers (particularly of the esophagus and stomach) and in a separate project, the transition from a healthy heart to cardiac hypertrophy and heart failure. We aim at a comprehensive, integrated view of pathology to develop personalized diagnostic, prognostic, and therapeutic approaches to disease. Service Activities
Associate Director for Laboratory Medicine and Medical Director of Laboratory Informatics
My clinical interests are centered on efficient laboratory management and provision of user-friendly laboratory information and interpretation to optimize patient care. As a clinical laboratorian and research scientist, I am interested in using large-scale data analysis and computational approaches to understand and guide efficient use of clinical laboratory tests to improve patient care.